Mexico City to San Luis Potosí bus with Senda
Senda buses from Mexico City Northern Bus Station to San Luis Potosí Bus Station (Terminal Terrestre Potosina): around 6h 25min, 5 departures on a typical weekday and fares from MX$587.
Why travel with Senda from Mexico City to San Luis Potosí
Grupo Senda has run buses in northern Mexico since 1934. On the Mexico City to San Luis Potosí route you get:
Adjustable seats
Wi-Fi on board
Power sockets
Restroom on board
Air conditioning
Luggage included
Onboard entertainment
Seat belts and monitored buses
Digital ticket
Digital ticket
Directly to your email
Secure payment
Pay online in MXN or your currency
Book in your language
English, Spanish and more
Book your Mexico City to San Luis Potosí bus
Compare every Senda departure for your date, choose your seat and pay online. Your e-ticket arrives by email. The answers to the most common questions are below.
Mexico City to San Luis Potosí by bus at a glance
5 departures on a typical weekday
First bus 8:45 AM, last bus 11:59 PM
From Mexico City Northern Bus Station
To San Luis Potosí Bus Station (Terminal Terrestre Potosina)
Around 6h 25min travel time
About 415 km, fares from MX$587
Mexico City to San Luis Potosí by bus: schedule, stations and trip
On Wednesday, November 25, 2026, the booking flow showed 5 Senda departures from Mexico City Northern Bus Station to San Luis Potosí Bus Station (Terminal Terrestre Potosina). Departure times that day: 8:45 AM, 2:00 PM, 4:30 PM, 7:00 PM, 11:59 PM.
Schedules change by date and season, so search your travel date to see the exact times and fares.
Where the bus leaves from
Mexico City Northern Bus Station, Eje Central Lázaro Cárdenas 4907, Gustavo A. Madero, Mexico City. The Northern Bus Station (Central del Norte) is next to Autobuses del Norte station on Metro Line 5. Authorized taxis can be booked at the official taxi booths inside the terminal.
Where the bus arrives
San Luis Potosí Bus Station (Terminal Terrestre Potosina), Carretera México km 2.5 / Blvd. San Luis, San Luis Potosí. The Terminal Terrestre Potosina (TTP) is on the east side of the city; a taxi or ride-hailing app takes about 15 minutes to the historic center.
The trip
The trip covers about 415 km, mostly on highway 57 via Querétaro. Senda buses take around 6 hours 25 minutes (between 5h 20min and 6h 25min depending on the departure). Traffic, roadworks and checkpoints can add time.
Station guides
Address, access and every Senda departure: San Luis Potosí Bus Station (Terminal Terrestre Potosina).
Arriving in San Luis Potosí
San Luis Potosí is a colonial state capital with a UNESCO-listed stretch of the Camino Real de Tierra Adentro, the Plaza de Armas and cathedral, the Teatro de la Paz and lively pedestrian streets. It is also the gateway to Real de Catorce in the Altiplano and to the waterfalls and rivers of the Huasteca Potosina.